肺出血模型研究进展【参考】.docVIP

肺出血肺出血肺出血-肾炎综合征（Goodpastures syndrome）可能系病毒感染和/或吸入某些化学性物质引起原发性肺损害由于肺泡壁毛细血管基膜和肾小球基底膜存在交叉反应抗原，故可以引起继发性肾损伤。明确的病因尚未证实，但多推测和感染特别是病毒感染有关。特征为咯血肺部浸润、肾小球肾炎、血和累及的组织中有抗基底膜抗体多20～30岁的男性青年肺出血-肾炎综合征The research progress about animal models of Goodpastures syndrome Abstract：Goodpastures syndrome may be caused by viral infection and inhalation of certain chemical substances. It can cause secondary renal injury due to the cross-reactive antigens between alveolar wall capillary basement membrane and glomerular basement membrane. The explicitly nosogenesis hasn’t been proved，but we conjecture that it is related t