微生物基因组与药靶研究2010.pptVIP

Microbial Genomics forAntibiotic Target Discovery微生物基因组与药靶研究 The Need for Novel Antibiotics The perception of having solved at least large parts of the problem of infectious diseases led to a subsequent decline in antibacterial research and development activities. Medical progress itself led to an increase in the numbers of elderly and immune-compromised patients, who increasingly became infected by a wide spectrum of pathogens for which the older antibiotics often have not been optimized. Most importantly, due to their relatively high mutation rates, short generation times, and various mec