第42章 四环素类及氯霉素类抗菌素.pptVIP

* Tetracyclines Chloramphenicol Chapter 42 §1 Tetracyclines natural drugs：tetracyclines 四环素 semisynthetic drugs: doxycycline多西环素 minocycline米诺环素 一. natural tetracycline ： Tetracycline 四环素 1. The absorption is impaired by food, metal ion (Ca2+, Mg2+,Fe2+, Al3+), and antacids. 食物、高价阳离子和抗酸药可减少 药物吸收 pharmacokinetics 2. the concentration in the foetus and breast milk 3. -bind to bones and teeth 沉积于骨、牙组织 4. Excretion: the bile and urine 主要原形肾排及胆汁排泄 broa