医学免疫学Introduction.案例分析.pptVIP

免疫系统的基本组成 免疫器官（organs） 骨髓（Bone marrow） 各类血细胞和免疫细胞发生的场所 B 细胞分化成熟的场所 体液免疫应答的场所 Segregation of B cells and T cells in alymph node 现代免疫学时期 抗体多样性和特异性的遗传基础 T细胞抗原受体的基因克隆 免疫遗传学和MHC限制性的发现 细胞因子及其受体 信号转导的研究 21世纪免疫学发展趋势 基础免疫学 临床免疫学 免疫应答的机制将得到更深刻的阐明 免疫学与临床医学的交叉渗透 Summary Immune Funtions Normal Manifestations Abnormal Manifestations Immune defense Immune homeostasis Immune surveilance resisting invasion of pathogens Neutralizing toxins Immune tolerance to self components Killing transformed cells Controlling persistence infection Hypersensitivity reaction Immunodeficiency diseases Autoimmune diseases tumor Persistent viral infection Immune functions and Menifestations Summary Innate immunity Adaptive immunity Manner of acquiring Phase of effect Immune memory Congenital,exist with born PRR No Acquired by antigen stimmulation after birth TCR BCR Have immune memory cells produced Comparison of innate immunity and adaptive immunity No antigen specificity Prompt Develops slowly, Antigen specificity Antigen recognition receptor Bone marrow spleen BCR Constitute of the immune system MATL CD TCR Immune organ central perpheral Immunocytes Immune molecule membrance secretory thymus Bursa of fibricius Lymph node SATL innate adaptive MHC CKR CAM Ig complement cytokine T B monocytes macrophage DC neutrophils eosinophils basophils Mast cells erythrocytes platelets 中枢免疫器官（central immune organ） 组成：胸腺、骨髓 功能：免疫细胞发生、分化、发育和成熟的场所 外周免疫器官（peripheral immune organ） 组成：淋巴结、脾、粘膜免疫系统 功能：成熟的Ｔ细胞、Ｂ细胞定居的地方，也是 产生免疫应答的部位 第二章 免疫器官和组织 Chapter 2 Immune organ and tissue 胸导管 扁桃腺 淋巴结 阑尾 淋巴管 骨髓 脾 胸腺 Yellow, primary lymphoid organs 初级淋巴器官 Blue, secondary lymphoid organs 次级淋巴器官 HSC: pluripotent hematopoietic stem cell 骨髓多能造血干细胞（HSC） 髓样祖细胞 Myeloid progenitor 淋巴样祖细胞 Lymphoid progenitor 粒细胞 单核细胞 树突状细胞 红细胞 血小板 B细胞 NK细胞 T细胞 A General Model of Hematopoiesis Kenneth Kaushansky, M.D. N Engl J Med 2006;354:2034-45. Localization of MKs in BM of living mice. SCIENCE 2007 Flow and fragmentation In b