Wnt信號通路在人胎盘滋养层细胞侵袭分化过程中的研究进展.docxVIP

Wnt 信号通路在人胎盘滋养层细胞侵袭、分化过程中的研究进展 李宁 综述 刘娟 审校摘要：滋养细胞是胎盘组织的主要细胞类型，其正常的增殖、分化、侵袭是胚胎成功着床的关键。研究发现Wnt 信号通路的适度激活可促进绒毛滋养细胞的侵袭, 为胚胎的成功着床提供条件。Wnt信号转通路的异常可能降低滋养细胞的增殖、分化及侵袭能力，影响新生血管的形成，导致胎盘浅着床，从而引发多种病理妊娠的发生。本文就Wnt 信号通路在人滋养细胞增值、分化、侵袭过程中的作用进行阐述。关键词：Wnt 信号通路；滋养细胞；增殖；分化；侵袭滋养细胞是胎盘组织的主要细胞类型，其正常的增殖、分化、侵袭是胚胎成功着床的关键 ADDIN EN.CITE EndNoteCiteAuthorKnofler/AuthorYear2013/YearRecNum452/RecNumrecordrec-number452/rec-numberforeign-keyskey app=EN db-id=zt5zfpdav0w208e2avovwxelzfvwz009trzd452/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthorKnofler, M./authorauthorPollheimer, J./author/authors/contributorsauth-addressDepartment of Obstetrics and Fetal-Maternal Medicine, Reproductive Biology Unit, Medical University of Vienna Austria./auth-addresstitlestitleHuman placental trophoblast invasion and differentiation: a particular focus on Wnt signaling/titlesecondary-titleFront Genet/secondary-title/titlesperiodicalfull-titleFront Genet/full-title/periodicalpages190/pagesvolume4/volumeedition2013/10/18/editiondatesyear2013/year/datesisbn1664-8021 (Electronic)#xD;1664-8021 (Linking)/isbnaccession-nuaccession-numurlsrelated-urlsurl/entrez/query.fcgi?cmd=Retrieveamp;db=PubMedamp;dopt=Citationamp;list_uidsurl/related-urls/urlscustocustom2electronic-resource-num10.3389/fgene.2013.00190/electronic-resource-numlanguageeng/language/record/Cite/EndNote[1]。当滋养细胞增殖、分化及细胞凋亡发生异常时，滋养细胞的侵袭能力降低，容易引起反复自然流产、子痫前期和胎儿宫内生长受限等多种妊娠疾病的发生 ADDIN EN.CITE ADDIN EN.CITE.DATA [2,3,4]。研究表明滋养细胞的增殖、分化和侵袭受到严格的空间和时间的调控，其功能的改变，主要依靠信号传导通路传递分子信息来实现 ADDIN EN.CITE EndNoteCiteAuthorKnofler/AuthorYear2013/YearRecNum452/RecNumrecordrec-number452/rec-numberforeign-keyskey app=EN db-id=zt5zfpdav0w208e2avovwxelzfvwz009trzd452/key/foreign-keysref-type name=Journal Article17/ref-typecontributorsauthorsauthorKnofler, M./authorauthorPollheimer, J./author/authors/contributorsauth-addressDepartment of Obstetrics and Fetal-Maternal Medicine, Reproductive Biology U