KrebsCycle(aka,tricarboxylicacid(TCA)cycle,citricacid.pptVIP

Kreb’s Cycle (aka, tricarboxylic acid (TCA)cycle, citric acid cycle) “The wheel is turnin’ and the sugar’s a burnin’” Overall goal Makes ATP Makes NADH Makes FADH2 Requires some carbohydrate to run Watch for reaction coupling Geography Glycolysis in the cytosol Krebs in mitochondrial matrix Mitochondrion Outer membrane very permeable Space between membranes called intermembrane space (clever huh!) Inner membrane (cristae) Permeable to pyruvate, Impermeable to fatty acids, NAD, etc Matrix is inside inner membrane Conversion of pyruvate to Acetyl CoA 2 per glucose (all of Kreb’s) Oxidative de