CHAPTER 3 Pharmacokinetics ( body acts on drug ).pptVIP

CHAPTER 3  Pharmacokinetics  （ body acts on drug ） A drug molecule moves from a side of membrane relatively high concentration to another side of low concentration without requiring energy, until an equilibrium has been achieved on both sides of the membrane. Nonionized form Ionized form  　 k1 [H+][A-]　 　 k1　 [H+][B] Ka＝──＝───── Ka＝──＝ ──── 　 k2 [HA] k2 [BH+]  　 [A] [B] pKa＝pH－log ─── pKa＝pH－log ───