银屑病和皮炎湿疹患者血清唾液酸的测定.docx.docxVIP

银屑病患者白细胞流变性和白细胞CD18表达及血清sICAM-1浓度的变化银屑病患者白细胞流变性和白细胞CD18表达及血清sICAM-1浓度的变化中华皮肤科杂志 1998年第2期第31卷 论著作者：刘成玉　王桂芝　谭润鸾单位：266021 青岛医学院诊断学教研室(刘成玉　谭润鸾)，皮肤病研究所(王桂芝)关键词：银屑病；细胞粘着分子；白细胞流变性【摘要】　目的　探讨白细胞流变性和细胞粘附分子(CAMS)表达与银屑病的关系。方法　采用ELISA法、红细胞变形能力测定仪和体外血栓血小板粘附两用仪检测了115例银屑病患者和89例健康人白细胞CD18表达、血清可溶性细胞间粘附分子-1(sICAM-1)浓度、白细胞滤过指数(LFI)和白细胞粘附率(LAR)的变化。结果　银屑病患者白细胞CD18表达、sICAM-1浓度、LFI和LAR均明显增高，与对照组比较差异均有显著性，且随着银屑病皮损加重，各指标增高逐渐明显。银屑病患者LFI、LAR与白细胞CD18表达和sICAM-1浓度呈正相关，LFI与LAR呈正相关。结论　白细胞流变性异常和细胞粘附分子表达增高与银屑病发病及皮损严重程度有关。The Changes of Leukocyte Rheology, Expression of Leukocyte CD18 and the Concentration of Serum Soluble Intercellular Adhesion Molecule-1 in Patients with PsoriasisLiu Chengyu, Wang Guizhi, Tan Runluan. Department of Diagnostics, Qingdao Medical College, Qingdao 266021【Abstract】　Objective　To explore the correlation between the leukocyte rheology, cell adhesion molecule(CAM) expression and psoriasis.Methods　Enzyme linked immunosorbent assay(ELISA), erythrocyte deformability apparatus and in vitro thrombus and platelet adhesion dual-purpose apparatus were used to determine the changes of leukocyte CD18 expression, levels of serum soluble intercelular adhesion molecule-1(sICAM-1), and the changes of leukocyte filtration index(LFI) and leukocyte adhesion rate(LAR).Results　The leukocyte CD18 expression, sICAM-1 level, LFI and LAR were significantly increased in patients with psoriasis than those in controls(P＜0.01), and along with the exacerbation of psoriatic skin lesions all the above parameters increased (P＜0.01). The LFI and LAR in the patients were positively correlated to the expression of leukocyte CD18 and the sICAM-1 concentration (r=0.718, 0.669, 0.626, 0.680, P＜0.01), LFI was positively correlated to LAR (r=0.588, P＜0.01). Conclusion　These results indicated that the abnormalities of leukocyte rheology and the increase of CAMs expression were closely related to the pathogenesis of psoriasis and the severity of psoriatic skin lesions.【Key words】　PsoriasisCell adhesion moleculesLeu