粘附分子抑制剂课程.pptVIP

* * * * * * * * * The SAM inhibitor Natalizumabdecreases MM cell growth in the bone marrow microenvironment: therapeutic implications Week report topic background knowledge Natalizumab：a recombinant humanized IgG4 monoclonal antibody, which binds integrin-a4, in MM; integrin: cell surface receptors that mediate both cell-cell and cell-extra cellular matrix adhesion; fibronectin: strong adhesive components for MM cells via interaction of a variety of integrins including integrin-a4。 MM细胞的粘附过程 骨髓基质细胞 促进MM细胞增殖 整合蛋白 MM 细胞 Summary Integrin-a4 expression in the MM bone marrow microenvironment；