神经影像学在儿童癫痫管理中的地位课程.pptVIP

MALFORMATIONS RELATED TO ABNORMAL PROLIFERATION OF NEURONS AND GLIA Focal Cortical Dysplasia was originally described in patients who were treated surgically for drug-resistant epilepsy. first identified as a distinct neuropathological entity in 1971 by Taylor and colleagues The histologic abnormalities are usually restricted to one lobe or a smaller segment and include local disorganization of the laminar structure, large aberrant neurons, isolated neuronal heterotopia in subcortical white matter, balloon cells, giant and odd macroglia, foci of demyelination, and gliosis of adjacent white mat