分子细胞生物学课程.pptVIP

* 分子细胞生物学 IIMolecular CELL BIOLOGY Series II Chapter 3: Cell Chemical Composition Water, ions, Protein (enzyme), nucleic acid, carbohydrate, Lipoid 1. The structure overview: 2. Water: a. Hydrophobic effect: b. Hydrogen bond: c. Hydration shell: 3. Ions: HIV integrase: 4. Biomacromolecules: 66 Human Enzymes 20 bacterial, viral, fungal or parasital enzymes Enzymes are the target of ~ 40% current drug targets Nat Rev 2002 5. Enzymes: Largest Class of Marketed Drugs and Largest Class of Drug Targets Landry et al Fundamentals Clinical Pharmacology 2007, 22, 1 Chapter 4: Cell Membrane a