溶血性贫血探讨.ppt

Hereditary HA Membrane abnormalities Enzymopathies Plasma constituent abnormalities RBC Membrane Structure + + Plasma IntegralProteins Peripheral Proteins Lipid Bi-Layer — — Lipid Bi-Layer RBC Cytoplasm Membrane Abnormalities Spherocytosis Elliptocytosis Pyropoikilocytosis Stomatocytosis Membrane Abnormalities See figure 17-1 Excess membrane cholesterol RBC inclusions Senescent RBC Complement coated RBC Antibody coated RBC Rigid RBC Spleen: Effects on RBCs Hereditary Spherocytosis Defect: RBC protein defects affecting spectrin Pathophysiology Increased Na+ permeability ? RBC rigidity ? Destru