普外科医生病理1(免费阅读).ppt

* indiscernible [,indis?:n?bl] adj. 1. difficult or impossible to perceive or discern an indiscernible increase in temperature 2. barely able to be perceived the transition was almost indiscernible indiscernible [,indis?:n?bl] adj. 不可识别的，难以觉察的，难以辨别的；觉察不出的 n. 不可识别的事物；无法辨认的事物 1 难识别的 2察觉不出 3分辨不清的 * * * * * * * * * * * * * * The Interstitial cell of Cajal (ICC) is a type of cell found in the gastrointestinal tract. It serves as a pacemaker that triggers gut contraction.[1] Many types of smooth muscle tissues have now been shown to contain ICC, but with few exceptions the function of these cells is not known and is currently an area of active research. An international society (International Society for ICC, ) has recently been formed to provide a forum to discuss research in ICC in a variety of tissues. Santiago Ramón y Cajal (1 May 1852 – 17 October 1934) was a Spanish histologist, physician, pathologist and Nobel laureate. His pioneering investigations of the microscopic structure of the brain were so original and influential that he is considered by many to be the greatest neuroscientist of all time.[1] His skills as an artist allowed him to make hundreds of drawings so beautiful and lucid that many of them are still used for educational purposes today.[2] * C-kit Four-μm thick sections were prepared from two paraffin blocks taken from the dissected fragments. One block was used for hematoxylin and eosin (HE) staining and for detailed histological examination and the other was used for immunohistochemistry(11-12). After blocking endogenous peroxidase activity with 3% hydrogen peroxidase in methanol, sections were incubated for 40 min for antigen retrieval. After treatment with 10% normal goat serum for 10 min to block nonspecific protein binding, a 1:100 dilution of mouse monoclonal antibody against c-kit human oncoprotein (CD117, Novocastra Laboratories Ltd, Newcastle-upon-Tyne, UK) was applied to the tissues and the slides were kept overnight at room tempe