免疫生物学作业20130110 - 副本.docVIP

Recognition of bacteria by mannose-binding lectin can lead to their destruction by the same mechanisms as recognition by antibody. Explain why this is so, and describe additional common features between these pathways of pathogen recognition 答：（1）无论是甘露糖凝集素途径还是经典途径，都需要经过一系列的反应使病原体表面结合大量的C3b分子，通过C3b分子发挥进一步的功能。由于作用的中间体相同，所以两条途径最终破坏细菌的机制以相同。 在细胞表面聚集C3b发挥作用之后的途径都是完全相同的；而在这一步骤之前，两条途径也有很多相似之处：经典途径第一个被活化的蛋白C1q和甘露糖凝集素与丝氨酸蛋白酶形成的复合物类似，都是由六个相同的球状头部和胶原状尾部组成的六聚体；经典途径和甘露糖凝集素途径都在病原体表面形成C4b和C2a组成的C3转化酶。 The innate immune system uses two different strategies to identify pathogens: recognition of nonself and rec