丙二醛、超氧化物歧化酶和.doc

丙二醛、超氧化物歧化酶和活性氧对2型糖尿病患者胰岛β细胞功能的影响 【摘要】目的： 探讨2型糖尿病患者胰岛β细胞功能与氧化应激的关系。 方法 2013年1月至2014年10月2型糖尿病患者100例为DM组、糖耐量受损的患者55例为IGT组和健康就诊者30例为对照组，测定3组血浆丙二醛(MDA)、超氧化物歧化酶 （SOD)和活性氧（ROS)水平，采用稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)以及胰岛素敏感指数(ISI)评价胰岛β细胞功能。 结果 ： GDM组患者MDA、ROS 、OMA-IR、HOMA-IR水平明显高于IGT组和对照组， IGT组和对照组HDL-C、SOD、HOMA-β、ISI水平明显低于GDM组，差异均有明显的统计学意义（p＜0.05），HOMA-IR与MDA和ROS呈现明显的正相关（p＜0.01）,与SOD呈现明显的负相关（p＜0.01）；HOMA-β与MDA和ROS呈现明显的负相关（p＜0.01）,与SOD呈现明显的正相关（p＜0.01），ISI与MDA和ROS呈现明显的负相关（p＜0.01）,与SOD呈现明显的正相关（p＜0.01）；Logistic回归分析显示：FINS，MDA，SOD，ROS是影响胰岛β细胞功能的主要因素。 结论：2型糖尿病患者胰岛β细胞功能受损可能与氧化应激有关。 【关键词】：2型糖尿病患者；氧化性应激；胰岛β细胞 Influence of MDA 、SOD and ROS on islet beta-cell function of type 2 diabetic patients 【abstract】Objective: To explore the relationship between islet beta-cell function and oxidative stress.Methods：The plasma?malondialdehyde?(MDA),? superoxide dismutase?(SOD)and reactive oxygen species?(ROS)?level of 100 patients with type 2 diabetes mellitus （DM group ），55 patients with impaired glucose tolerance（IGT group） and 30 normal persons (control group) were compared from January 2013 to October 2014。Using the?homeostasis model assessment insulin resistance index?(HOMA-IR),?insulin secretion index?(HOMA-?β) and insulin sensitivity index?(ISI) evaluation of beta cell of islet function.Result：Patients in group GDM?MDA,?ROS,?OMA-IR,?HOMA-IR?levels were higher in the IGT?group and the control group,?IGT?group and control group?HDL-C,?SOD,?HOMA-?β, ISI levels were significantly lower than that in GDM group, significant differences were significant (P 0.05), there is an obvious positive correlation between HOMA-IR and MDA and ROS?(P 0.01), showed a significant negative correlation with SOD?(P 0.01); significant negative correlation of HOMA-?β and MDA and ROS?(P 0.01), showed a significant positive correlation with SOD(P 0.01), showed a significant negative correlation between ISI and MDA and ROS?(P 0.01), presents the obvious a positive correlation with SOD?(P 0.01); Logi