2003-雷替曲塞猪模型腹腔灌注毒性及价值评估讲述.docVIP

1页 Signature:?Med Sci Monit, 2003; 9(1): BR37-42 签名：医学信息，2003；9（1）：溴37-42 PMID:分类号 W W W .M E D SCI MONIT.COM Basic Research 基础研究 Received: 2002.03.27 收到:2002.03.27 Accepted: 2003.01.03 接受:2003.01.03 Published: 2003.01.28 发表:2003.01.28 Authors’Contribution: 作者的贡献: A Study Design A个研究设计 B Data Collection B数据收集 C Statistical Analysis C统计分析 D Data Interpretation D维数据解释 E Manuscript Preparation E手稿准备 F Literature Search F文献检索 G Funds Collection G基金集合 Pharmacokinetics studies and toxicity profile 药代动力学研究和毒性 of raltitrexed used by intraperitoneal route 雷替曲塞腹腔路线 in normothermia in a pig model 在常温的猪模型 Diem Nguyen 1 abcde, 吴庭艳阮 1份 专题 Claude Emond 1 abcde, 克劳德等 1份 专题 Yves E. Leclerc 1abcde, 伊夫·勒克莱尔 1份 专题 Igor Sherman 2 abcde, 伊戈尔·谢尔曼 2 份 专题 Pierre Dubé 1 abcde 皮埃尔·杜布 1份 专题 Department of Surgery, Maisonneuve-Rosemont Hospital, University of Montreal, Montreal, Canada 外科学系,麦松尼喔-罗斯医院,大学蒙特利尔,加拿大蒙特利尔 AstraZeneca Canada 阿斯利康加拿大 Source of support: AstraZeneca Canada Inc. 资源的支持由:阿斯利康加拿大公司。 Background 背景 Material/Methods材料/方法 Results 结果 Conclusion 结论 key words 关键词 Summary 摘要 To define the pharmacokinetic and toxicity profile of raltitrexed administered by intraperi-toneal route in a normothermic pig model. 定义的 药代动力学和毒性雷替曲噻 由腹腔腹膜路线 性常温 猪 模型。 Twenty-one female pigs were divided in three groups. Under general anesthesia, pigs in groups 1 and 2 underwent laparotomy with resection of a small hepatic wedge, bowel anasto-mosis and portal and systemic vein catheterization. This was followed by an intraperitioneal deliveryof raltitrexed: a dose of 1 mg was given to group 1 pigs, whereas group 2 received 2mg. Serial sampling of portal blood, systemic blood and peritoneal fluid was then undertaken in both groups for pharmacokinetics studies. Pigs were followed daily for a period of 10 days after surgery with recordings of signs of tox