兰索拉唑治疗消化系统溃疡的临床效果及不良反应观察.docVIP

兰索拉唑治疗消化系统溃疡的临床效果及不良反应观察 　　[摘要] 目的 观察兰索拉唑治疗消化系统溃疡的临床效果及不良反应。 方法 选取本院2011年11月～2012年12月收治的86例消化系统溃疡患者，将其分成治疗组（43例）和对照组（43例）。治疗组患者采用兰索拉唑治疗，对照组患者采用奥美拉唑治疗，对比两组患者的治疗效果及不良反应发生率。 结果 治疗组患者的总有效率为93.02%，幽门螺杆菌根除率为90.70%；对照组患者的总有效率为76.74%，幽门螺杆菌根除率为67.44%，两组间比较，差异均有统计学意义（P0.05）。 结论 兰索拉唑治疗消化系统溃疡效果良好，不良反应较低，值得推广应用。 　　[关键词] 兰索拉唑；消化系统溃疡；临床效果；不良反应 　　[中图分类号] R573.1 [文献标识码] A [文章编号] 1674-4721（2013）11（a）-0078-02 　　Observe of the clinical effects and adverse reactions of lansoprazole for the treatment of peptic ulcer 　　LI Li 　　Department of Pharmacy，People′s Hospital of Pingxiang City in Jiangxi Province，Pingxiang 337055，China 　　[Abstract] Objective To observe the clinical effects and adverse reactions of lansoprazole for the treatment of peptic ulcer. Methods 86 patients with peptic ulcer in our hospital from November 2011 to December 2012 were selected as research objects and patients were divided into treatment group（n=43） and control group（n=43），the treatment group received lansoprazole and the control group received omeprazole，then treatment effect and adverse reaction incidence between the two groups were compared. Results The total effective rate and Hp eradication rate of the treatment group was 93.02% and 90.70% respectively，the total effective rate and Hp eradication rate of the control group was 76.74% and 67.44% respectively.The difference were all statistically significant（P0.05）. Conclusion Lansoprazole can be widely applied for treating peptic in both groups ulcer due to its better clinical efficacy and lower adverse reaction incidence. 　　[Key words] Lansoprazole；Peptic ulcer；Clinical effect；Adverse reaction 　　消化系统溃疡是临床常见疾病，发病率占总人口的5%～10%，本病绝大多数位于胃和十二指肠，临床表现为慢性、周期性、节律性中上腹部疼痛，常伴有恶心、呕吐等症状。兰索拉唑为新型抑制胃酸分泌的药物，对于消化系统溃疡疾病具有良好的治疗效果。基于消化系统溃疡疾病的病理特点，为详细了解兰索拉唑治疗消化系统溃疡的临床效果及不良反应，本研究选取本院2011年11月～2012年12月收治的86例消化系统溃疡患者的临床资料进行回顾性分析，现报道如下。 　　1 资料与方法 　　1.1 一般资料 　　选取本院收治的86例消化系统溃疡患者，经过临床诊断以及胃镜辅助检查均确诊为消化系统溃疡疾病，患者的临床症状表现为周期性、典型性腹痛。按患者住院尾号将其分为治疗组和对照组，治疗组43患者中，男29例，女14例；年龄22～63岁，平