可溶性细胞间粘附分子-1与老年-中国老年学和老年医学学会.docVIP

可溶性细胞间黏附分子1与老年 单纯收缩期高血压血管内皮功能的相关性研究 周亚丽 黄 榕 [摘要] 目的 探讨可溶性细胞间黏附分子-1（sICAM-1）与老年单纯收缩期高血压血管内皮功能之间的关系及其致高血压的发病机制。方法 采用病例-对照研究方法，选择2011-07——2012-07 入住新疆维吾尔自治区人民医院干保二科的老年单纯收缩期高血压（ISH）患者110 例作为ISH 组；老年原发性高血压（EH）患者110 例作为EH组；并选择年龄与之相匹配的血压正常者作为正常血压对照组；采用ELISA法测定血清可溶性细胞间黏附分子1(sICAM-1)、晚期糖基化终产物(AGEs)浓度，Griess 法测定血清一氧化氮含量；运用超声技术测定血流介导的内皮依赖性血管舒张功能(FMD)，动脉硬化检测仪测定颈-股动脉脉搏波传导速度(cfPWV)。结果 老年ISH、EH患者的sICAM-1、AGEs、cfPWV水平均高于正常血压对照组(P 0.01)，老年ISH、EH患者NO含量、FMD均低于正常血压对照组(P 0.01)；老年ISH患者的sICAM-1、AGEs及cfPWV均高于老年EH组(P 0.01)，sICAM-1与AGEs、cfPWV呈正相关( r = 0.728，P 0.01；r = 0.752，P 0.01)；sICAM-1与NO、FMD呈负相关(r = -0.794，P 0.01；r = -0.669，P 0.01)；多元线性逐步回归分析显示sICAM-1、cfPWV是FMD的危险因素。结论 老年单纯收缩期高血压患者体内sICAM-1水平明显升高，是导致血管功能异常的危险因素，可能与其他炎症分子一起参与了老年单纯收缩期高血压的发生发展。 关键词：单纯收缩期高血压、可溶性细胞间黏附分子-1、血流介导的内皮依赖性血管舒张 功能、脉搏波传导速度 A Study on the Correlationship between Soluble Intercellular Adhesion Molecule-1 and Vascular Endothelial Function with Elder Isolated Systolic Hypertension Zhou Ya-li Huang Rong (Dept 2 of Cadre Health Care，People, s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang 830001 China) 作者单位：新疆维吾尔自治区人民医院干保二科，新疆 乌鲁木齐 830001 通信作者：周亚丽，E-mail：ZHOUYALI111@163.com Abstract Objective To investigate the relationship between soluble intercellular adhesion molecule-1 (sICAM-1) and vascular endothelial function of patients with elder isolated systolic hypertension (ISH) and its pathogenic mechanism on hypertension．Metholds Using case-control study method，Choose 300 cases who were hospitalized in dept of 2 of Cadre Health Care of people, s hospital of Xinjiang Uygur Autonomous Region from July 2011 to July 2012,including 110 old patients with isolated systolic hypertension (ISH)as the ISH group； 110 essential hypertensions (EH) as the EH group；And 80 cases of age-matched persons with normal blood pressure as normal blood pressure control group. serum soluble intercellular adhesion molecule-1 (s