吲哚美辛和胰管支架在预防ERCP术后胰腺炎中作用的研究.docVIP

吲哚美辛和胰管支架在预防ERCP术后胰腺炎中作用的研究 　　摘 要：目的：观察应用吲哚美辛和胰管支架对ERCP术后胰腺炎（PEP）及高淀粉酶血症的预防作用。方法：将本院2年内ERCP检查术中导丝反复进胰管的336例患者随机分为两组，吲哚美辛组在ERCP术后45min直肠内给予吲哚美辛栓剂150mg，对照组在ERCP术中常规放置胰腺支架。ERCP术后观察患者有无腹痛，并于术后12h做生率（10.6%）无显著差异（P =0.28），而吲哚美辛组ERCP术后高淀粉酶血症的发生率（18.1%）显著低于胰管支架组（37.6%，P=0.005）。结论：直肠应用吲哚美辛较胰管支架可以预防ERCP术后高淀粉酶血症的发生。 　　关键词：十二指肠镜逆行胰胆管造影术；胰腺炎；吲哚美辛；胰管支架 　　Abstract：Objective To investigate the effect of prophylactic rectal indomethacin on post-ERCP hyperamylasemia and pancreatitis.Methods One hundred and sixty-eight patients who underwent ERCP for various reasons were randomly divided into indomethacin