医、技学院(华盛顿医疗手册培训-过敏和免疫学).pptVIP

Clinical Presentation The hallmark of PID is recurrent infections. Immunoglobulin A (IgA) deficiency is the most common immune deficiency, with a prevalence of 1 in 500 people. In 15% of cases, an associated immunoglobulin G (IgG) subclass deficiency is present. elevated levels of IgE. A marked increase in tissue and blood eosinophils may also be observed. Mutations in STAT3 have been linked to development of this disease (N Engl J Med 2007;357(16):1608). Initial evaluation should focus on identifying possible secondary causes of recurrent infection such as allergy, medications, and anatomic