2a. Biological database and genome browser.pptx

生物信息学Bioinformatics蒋庆华Qinghua Jiang生命科学与技术学院School of Life Science and Technology哈尔滨工业大学Harbin Institute of Technology Syllabus (课程提纲）第一章 生物信息学基础 （4+2学时) 第二章 生物数据库及基因组浏览器 （4+2学时）第三章 R语言程序设计 （2+2学时）第四章 基因芯片及其数据分析 （4+2学时）第五章 新一代测序技术及其数据分析 （4+2学时）第六章 生物信息学研究热点分析及研究实例 （4学时）Summary for the last lectureGenome featuresLength, GC% content of human genome,microRNA, lncRNA Genomics terminologyGene structureIntron, exon, UTR, CDSAlternative splicingRegulatory elementPromoter, enhancer, insulator and TFEpigenetics: histone modification ，DNA methylationOutlinePubMed database （文献）microRNADisease gene database (疾病基因）OMIM, GADmiR2DiseaseLncRNADiseaseSequence database （序列）Genebank、EMBL、DDBJFunctional annotation database of gene （功能注释）GenecardsGene Ontology (GO)KEGGGene expression database （基因表达）NCBI GEOThe Encyclopedia of DNA Elements (ENCODE) ConsortiumThe Cancer Genome Atlas (TCGA) （癌基因组计划）PubMed/pubmed/pubmed PubMed ? NCBI ? NLM ? NIHBiomedical literature database 24M citations from 4800 journals since 1948.Entrez is the retrieval system为什么要了解PubMed搜索已出版的论文可以实时跟踪感兴趣的研究领域或某学术大牛最新发表的论文PubMed ArticlesSearch by Author / Journal / DateBy author:Full name [au]: Xiaole Liu [au]By journal title: [ta]Full journal title or MEDLINE abbreviation: PNAS [ta]Index to get journal title “proceedings of the national”By date:yyyy/mm/dd [dp](具体某一天）Date range (:) or “last x days/months/years” （一段时间）Jun Liu [au] AND last 3 years [dp]Search Syntax and TagsBoolean: AND, OR, NOTField tagsFirst author [1AU], author [AU], full author [FAU], 1st author affiliation [AD]Title [TI], title/abstract [TIAB], text words [TW]Publication date [DP]Publication type [PT], journal title [TA], Language [LA]MeSH term [MH]Sorted by: Date, author, journalDetails: View and edit actual queryAdvanced search (高级搜索）“高级搜索”例子：搜索2014年1月1日至今发表的摘要或者论文题目里含单词lncRNA的所有综述论文文献提醒服务如何知道某篇感兴趣的论文发表后被哪些论文引用？Scholar googleSCI 科学引文索引OutlinePubMed database （文献）microRNADisease gene database (疾病基因）OMIM, GADmiR2DiseaseLncRNADiseaseSequence databa