普拉克索缓释片的临床应用要素.pptVIP

Of the 87 patients successfully switched to pramipexole sustained release (SR) , 72 (82.8%) did not require dose adjustment. In the ER group overall (n = 103), mean SR dosage was only marginally increased by 0.12 mg/d (from 2.63 to 2.75), for a ratio of 1:1.05. In the immediate-release (IR) group overall (n = 52), the increase was 0.09 mg/d (from 2.74 to 2.83), for a ratio of 1:1.03. Based on these data, a 1:1 mg overnight switch from pramipexole IR to SR can be recommended. However, a small proportion of patients may require some dose modification following switching1. Reference Rascol O, Ba