神经系统疾病伴发抑郁焦虑障碍的诊断治疗专家共识__培训课件.pptVIP

* Key Point Antidepressants may affect neuronal survival and growth Background Neuronal atrophy and cell death are thought to occur as a result of hyperactivity of the stress–response system in depressed patients, which increases adrenal glucocorticoid release and decreases BDNF levels, a factor critical for the survival and function of neurons in the adult brain1 The damaging effects of prolonged stress/depressive symptoms could contribute to the selective loss of volume of the hippocampus (a structure essential to learning and memory, contextual fear conditioning, and neuroendocrine regulati