Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidantHuperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant.docxVIP

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Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidantHuperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant.docx

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Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidantHuperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant

Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant, anti- apoptotic and anti-inflammatory mechanismsXIZHONG SUI and CHANGQING GAO Department of Cardiac Surgery, The PLA General Hospital, Medical School of Chinese PLA, Beijing 100098, P.R. ChinaReceived July 26, 2013; Accepted October 21, 2013 DOI: 10.3892/ijmm.2013.1546Abstract. Huperzine A (HupA), an alkaloid used in traditional Chinese medicine and isolated from Huperzia serrata, has been shown to possess diverse biological activities. The present study was undertaken to evaluate the cardioprotective potential of HupA in myocardial ischemic damage using a rat model of acute myocardial infarction. HupA significantly diminished the infarct size and inhibited the activities of myocardial enzymes, including creatine kinase (CK), the MB isoenzyme of creatine kinase (CK-MB), lactate dehydrogenase (LDH) and cardiac troponin T (cTnT). A significantly reduced activity of malondialdehyde (MDA) and elevated activities of superoxide dismutase (SOD), of the non-enzymatic scavenger enzyme, glutathione (GSH), as well as of glutathione peroxidase (GSH- PX) were found in the HupA-treated groups. Furthermore, decreased protein levels of caspase-3 and Bax, and increased levels of Bcl-2 were observed in the infarcted hearts of the rats treated with various concentrations of HupA. In addition, treatment with HupA markedly inhibited the expression of the nuclear factor-KB (NF-kB) subunit p65, tumor necrosis factor-a (TNF-a) and interleukin-1p (IL-1p). These findings suggest that the cardioprotective potential of HupA is associated with its antioxidant, anti-apoptotic and anti-inflammatory properties in acute myocardial infarction in rats.IntroductionMyocardial infarction is one of the most common ischemic heart diseases and a major cause of morbidity and mortality worldwide. It is a clinical syndrome arising from the sudden and persistent interruption of the myocardial blood supply,Corresp