VEGF检测在胸部恶性肿瘤中临床意义VEGF检测在胸部恶性肿瘤中临床意义.docVIP

VEGF检测在胸部恶性肿瘤中临床意义 马晨光 （黑龙江省医院胸外科，150036） 摘要：目的：探讨检测胸部恶性肿瘤患者外周血中血管内皮生长因子（VEGF）的临床意义。方法：32例健康志愿者作为正常对照组，45例肺癌患者，30例食管癌患者。采用ELISA方法检测外周血VEGF的含量，比较各分组间的差异。结果：肺癌、食管癌阳性观察组血清VEGF阳性表达率及含量明显高于正常对照组（P＜0.05）,VEGF的阳性表达率及含量在按不同的病理生理特征分组的肺癌、食管癌患者中表现出统计学差异（P＜0.05）。结论：VEGF水平对肺癌、食管癌患者有诊断价值。血清VEGF水平与肺癌、食管癌的病理生理特征、恶性行为密切相关。检测血清VEGF对于判定肺癌、食管癌病理生理特征有一定参考意义。VEGF可作为临床常用检测食管癌、肺癌的血清检测物。 关键词：血管内皮生长因子，肺癌，食管癌，ELISA The Clinical Value of Detection of Serum Level of VEGF in Esophageal Carcinoma MA Chen-guang (The Provincal Hospital of Heilongjiang 150036) Abstract ：Objective: To research the clinical value for thoracic malignant tumors by detection of the serum level of VEGF. Methods: The level of serum VEGF was determined by using enzyme-linked immunosorbent assay in 45 patients with lung carcinoma and 30 patients with esophageal carcinoma, compared with the levels of the controls in which there are 32 volunteers for health examination, and then the results were analyzed. Results: The serum levels and positive rates of VEGF in the positive group are higher than that in healthy group with statistic significant difference（P＜0.05）; There are significant difference in the serum levels and positive rates of VEGF in the different groups divided on pathophysiologic characters of lung carcinoma and esophageal carcinoma（P＜0.05）.Conclusion: The detection of serum VEGF may be valuable to the diagnosis of lung carcinoma and esophageal carcinoma. The serum level of VEGF in lung carcinoma and esophageal carcinoma patients were strongly correlated to the pathophysiologic characters and malignant behavior of tumor. There may be some reference value for the prognosis of the pathophysiologic characters of lung carcinoma and esophageal carcinoma by the combined detection of serum VEGF. Key Words: Vascular Endothelial Growth Factor; Lung carcinoma; Esophageal carcinoma，enzyme linked immunosorbent assay 肺癌、食管癌是常见的胸部恶性肿瘤，也是人类最常见的恶性肿瘤之一。我国是肺癌、食管癌的高发国家，近年来二者的发病率逐年升高。食管癌是消化道常见的恶性肿瘤之一，高发年龄在60～64岁。我国是世