KEGGandGO解析.pptVIP

吴子君 KEGG and GO 2016.04.16 KEGG Analysis 01 what is KEGG KEGG :Kyoto Encyclopedia of Genes and Genomes an integrated database resource for biological interpretation of genome sequences and other high-throughput data. Foubder of KEGG Minoru Kanehisa Professor Institute for Chemical Research Kyoto University Technical Director, Pathway Solutions Inc President, NPO Bioinformatics Japan Initiated of KEGG In 1995, KEGG database project as part of the Japanese Human Genome Program, in anticipation of the need for a reference knowledge base for biological interpretation of genome sequence data The main objective of KEGG has been to establish links from collective sets of genes in the genome to high-level functions of the cell and the organism Overview of KEGG Genome annotation the KO (KEGG Orthology) database for linking genes to high-level functions 直系同源(orthology)??是比较基因组学中最重要的定义。 直系同源的定义是： (1).在进化上起源于一个始祖基因并垂直传递的同源基因； (2).分布于两种或两种以上物种的基因组； (3).功能高度保守乃至于近乎相同，甚至于其在近缘物种可以相互替换； (4).结构相似； (5).组织特异性与亚细胞分布相似。 Genome annotation First, molecular functions are stored in the KO database and associated with ortholog groups in order to enable extension of experimental evidence in a speciic organism to other organisms Second, ortholog groups are defined in the context of KEGG pathway maps and other molecular networks, which are all cre-ated as networks of K number nodes KEGG KEGG KEGG Translation Bioinformatics AMR (Antimicrobial resistanceis) a universal problem in the management of infectious diseases and complications KEGG disease pathway maps for infectious diseases KEGG metabolic pathway maps for biosynthesis of antibiotics KEGG drug structure maps for the history of antimicrobial drug development KEGG DRUG entries for all drugs currently in use. Knowledge on AMR mechanisms is now organized in KEGG pathway maps and KEGG modules Translation Bioinformatics Gene Ontology Analysis 02 w