GeneMappingTheWhyandHowofMultipleQTLBrianS.pptVIP

QTL: Why and How UW-Madison PBPG Yandell ? 2007 Gene Mapping:The Why and How of Multiple QTLBrian S. Yandell why: strategy bias with single QTL advantages of multiple QTL how: software WinQTLCart intro R/qtl demo R/qtlbim demo Real knowledge is to know the extent of one’s ignorance. Confucius (on a bench in Seattle) outline What is the goal of multiple QTL study? Gene action and epistasis Bayesian vs. classical QTL QTL software options cross two inbred lines → linkage disequilibrium → associations → linked segregating QTL (after Gary Churchill) 1. what is the goal of QTL study? uncover u