ppt课件-topdowntherapyvs stepuptherapyinpediatricpatients（ topdowntherapyvs stepuptherapyinpediatricpatients）.pptVIP

Top Down Therapy vs Step Up Therapy in Pediatric Patients with new onset Crohn’s Disease Presenters Dr Ali Minhas M.B.B.S Dr Orooj Khan M.B.B.S Mentor Dr Maya D Srivastava M.D Background Top-down (TD) therapy with tumor necrosis factor inhibitors early in disease course of adult Crohns disease (CD) has been shown to result in decreased steroid dependence, hospitalizations, complications, and disease activity compared to conventional step-up (SU) therapy Background Anti-TNF is effective in pediatric patients with CD failing conventional step up therapy Data regarding Top Down therapy in p