混合細胞白血病英文讲义.docVIP

Good afternoon，everyone，today I will introduce something about acute mixed leukemia. My comtents include Overview，Clinical feature，Laboratory examination ?and diagnosis，Treatment,curative effect and prognoses，Conclusion. 3、 At first，I will introduce the overview of acute mixed leukemia.what is acute mixed leukemia(MAL)? Human acute leukemias (AL) are classified as myeloid or lymphoid according to cytomorphology and the expression of leukocyte differentiation antigens/CD-markers. However, in the minority of cases leukemic cells express both myeloid and lymphoid antigens,these leukemia are defined as mixed acute leukemia（MAL) 4、 MAL account for about 2-8% of total AL.It usually happens among old persons.The pathogenesis of MAL is not clear. 5、 As the picture shows MAL express both myeloid and lymphoid antigens,It contains three situation，myeloid and T-lymphoid antigens, myeloid and B-lymphoid antigens, myeloid and T+B-lymphoid antigens, as for T and B Lymphoid antigens express respectively or co-expressed in leukemia cells ，Which be Classified to MAL by some studies，there is no agreement about whether it be Classified to MAL. MAL includes three subtypes ：biphenotypic acute leukemia (BAL), acute biclonal leukemia and acute bilineal leukemia biphenotypic acute leukemia (BAL)refers to acute leukemia with a single population of blasts coexpressing markers of two different lineages.And the co-expression of several myeloid and lymphoid antigens in the same cells. This is schematic diagram of biphenotypic acute leukemia (BAL) acute bilineal leukemia means some leukemia cells express myeloid antigens，others express lymphoid antigens，the two kinds of cells are derived from a single population of multipotent stem cell. ?the two kinds of leukemia cells exist at the same time, or they don’t exist at the same time, they appear one after another within 6 months 11、The two figures are schematic diagrams of acute bilineal leukemia. 12、 acute biclonal leukemia refe