人重组生长激素对肝硬化门脉高压患者术后早期免疫功能的影响.docVIP

人重组生长激素对肝硬化门脉高压患者术后早期免疫功能的影响 nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 作者：刘小南 霍婷婷 王为忠 董光龙nbsp;nbsp;nbsp; 　【摘要】目的：探讨人重组生长激素（rhGH）对肝硬化门脉高压患者术后早期免疫功能的影响。方法：48例肝硬化门脉高压已行门奇静脉断流和脾切除术患者术后随机分为治疗组（n=24）及对照组（n=24），两组术后除常规治疗外，于术后第2天每天分别皮下注射rhGH和生理盐水2ml，连续注射7d。分别于术前第1天及术后第8天检测CD3、CD4、CD8T淋巴细胞亚群、NK细胞、血清IgG、IgM、IgA、TNFα和IIL2。结果：治疗组术后第8天CD4T淋巴细胞、NK细胞和IL2水平较术前显著增高，血清IgG、IgM和IgA无变化。结论：rhGH可提高肝硬化门脉高压患者术后早期机体细胞免疫功能，对体液免疫功能影响不大。 nbsp;nbsp;nbsp; 【关键词】人重组#12539;生长激素#12539;高血压，门静脉#12539;免疫，细胞#12539;抗体生成 nbsp;nbsp;nbsp; The effect of postoperative recombinant human growth hormone on immunity function of patients with liver cirrhosis and portal hypertension nbsp;nbsp;nbsp; 【ABSTRACT】Objective:To investigate the effect of immunity function of the patients with Liver cirrhosis and portal hypertension applied with recombinant human growth hormone after operation.Methods:48 patients with liver cirrhosis and portal hypertension who received portal azygous disconnection and splenectomy were randomly assigned 2 groups,group control (n=24) and group therapy (n=24),except normal therapy,the patients of 2 group were separately cured by hypodermic injection of rhGH(8u,group therapy) and normal saline (2ml,control group) at second day for 7 days after operation.The CD3,CD4 and CD8 T lymphocyte subsets,NH cell,IgG,IgM,IgA,TNFα and IL2 in serum were determined at 1 day before operation and at 8 day after operation.Results:According to preoperation,the level of CD4 T lymphocyte,NK cell and IL2 in group therapy were markedly heightened at 8 day postoperation,simultaneously IgG,IgM and IgA in serum do not change.Conclusion:rhGH can promote the cell immunity function,does not impact the humor immunity function in the forepart after operation. nbsp;nbsp;nbsp; 【KEY WORDS】Recombinant human growth hormone#12539;Hypertension,portal #12539;Immunity,cellular#12539;Antibody formationnbsp;nbsp;nbsp; 　nbsp;人重组生长激素（recombinant huamn growth hormone,rhGH)除促进合成代谢和增殖分化功能，还