冠脉搭桥术中桥血流量与狭窄程度间多重回归性的研究.docVIP

冠脉搭桥术中桥血流量与狭窄程度间多重回归性的研究 关键词： 冠状动脉旁路移植术 nbsp;nbsp;nbsp; 【摘要】nbsp; 目的nbsp; 应用即时血流测量技术建立冠脉移植桥血流量多重回归方程。方法nbsp; 健康成年犬12只，在非体外循环心脏不停跳中行搭桥手术，术中应用即时血流测量仪(Transit Time Meter;Transonic 2000，NY.USA)对不同的狭窄级别分别运用血管活性药物和影响心率的药物产生相应的血压变化和心率变化，同时记录血管桥血流量的变化。结果nbsp; 吻合口狭窄程度和动脉血压对血管桥血流量值的影响最大。可以建立血管桥血流量值与吻合口狭窄程度、动脉血压、心率间的多重回归方程：F＝-14.41+0.17BP+9.57S，狭窄严重程度与桥血流量直线相关；血压与桥血流量直线相关。心率变化与桥血流量不具有统计学意义的相关性。结论nbsp; 桥血流量值与吻合口狭窄程度、动脉血压之间有直线相关，提示可在人体建立桥血流的回归方程，评估血管桥通畅性。 nbsp;nbsp;nbsp; 【关键词】nbsp; 即时血流测量技术nbsp; 冠状动脉旁路移植术nbsp; 桥血流量nbsp; 多重回归方程 nbsp;nbsp;nbsp; Can we establish a multiple regression equation concerned the flow volume of coronary artery graft? nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; 【Abstract】nbsp; Objectivenbsp; To establish a multiple regression equation and estimate the correlation between stenosis of anastomasis、BP and HR and flow volume of graft.Methodsnbsp; Twelve adult healthy dogs of both sexes weighing 27.62±1.63kg were anesthetized and their chests were opened with a medial sternotomy.There are four groups produced with four catheters divided in non-stenosis、33% stenosis、50% stenosis and 75% stenosis.Hemodynamic parameters including flow volume of graft、PI、wave of flow、heart rate (HR)、blood pressure (BP)、central venous pressure (CVP) were recorded.Resultsnbsp; There were obvious linear correlation between anastomasis stenosis and BP with flow volume of graft.Multiple regression equation:F＝-14.41+0.17BP+9.57S P＜0.001.Conclusionnbsp; There were obvious linear correlation between anastomasis stenosis and BP with flow volume of graft.When there are more variables，we can establish a multiple regression equation in human. nbsp;nbsp;nbsp; 【Key words】nbsp; transit-time flow measurementnbsp; off-pump coronary artery bypassingnbsp; flow volume of graftnbsp; multiple regression equation nbsp;nbsp;nbsp; 冠状动脉旁路移植术是治疗冠心病的重要手段，其中无泵搭桥术式使患者避免了体外循环所产生的并发症，正得到迅速发展，但是由于该吻合技术要求较高，增加了吻合口狭窄导致血管桥早期堵塞的机率［1，2］，而手术期间测定桥的血流量可以提供一种比较客观的指标。即时血流测量仪操作简单，准确率较高，可以在搭桥术中提供血管桥通畅性的