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利尿药与β-受体阻滞剂单用及联合应用治疗高血压的不良反应 张芳1 马松涛△ (成都医学院 1.临床医学系 △ 成都医学院药理教研室 四川 成都610083) 摘要: 高血压病是一种因血管神经调节障碍而引起的一种动脉压力升高的慢性疾病，它最大的危害在于对全身血管造成长期超极限的额外压力，导致血管的脆性损伤，最终引起血管的破裂、堵塞。大量循证医学资料表明，要改善高血压的长期预后，绝大多数患者通常需要终身服用降压药物，而且大多数需要服用2种以上抗高血压药物。本文就利尿药与β-受体阻滞剂单独及联合应用治疗高血压中的不良反应作一综述。 关键词：利尿剂 β-受体阻滞剂 高血压 不良反应 The adverse reactions of Diuretics and β-blockers monotherapy and combination treated hypertension ZHANG Fang1 MA Song Tao △ (Chengdu Medical College 1. clinical medicine，△. The Department of Pharmacology，Chengdu Sichuan 610083) Abstract：Hypertension is a chronic diseasea arterial pressure rise due to blood vessels and Neural regulation barriers.The greatest harm lies in long-term systemic vascular additional pressure over the limitation, leads to the brittle damage of blood vessels and eventually causes the rupture of blood vessels and blocking. A large number of evidence-based medical datas indicate that most patients usually need life-long drug therapy to improve the long-term prognosis of hypertension, and most need to take more than 2 anti-hypertensive drugs. This review is about the adverse reactions of Diuretics and β-blockers monotherapy and combination treated hypertension . Key words：Diuretics β-receptor blockers Hypertension Adverse reactions参考文献： 贾桂花,侯爱君,聂玉红.高血压患者服药依从性影响因素及应对措施探讨[J].社区医学杂志,2009,7(23):64-67. Krum HCatheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study.Lancet.2009,373(9671):1275-1281. 史玉梅,桂呜,夏美玉.高血压患者642例降压药应用分析[J].现代中西医结合杂志,2010 (1),19(1):49-50. 王建华.高血压药物治疗的原则[J].中国实用医学,2009（12）,4（4）:219-220. 屠晓燕,赵明明.浅谈高血压患者的合理用药[J].中国保健,2008,16(6):218-219. 张巧丽,刘智明.高血压的临床诊治[J].中国民族民间医药,2009(2),95-95.周炜,郭小梅.高血压药物治疗进展[J].医药导报,2010(1),29(1):36-39. 王风秀.合理应用降压药的新概念及误区[J].中国医疗前沿,2009(9),4(18):80,102. 刘惠侠.长效袢利尿药托拉塞米临床研究进展[J].世界临床药物,2004,25(8):495-498,504. ]Reyes AJ.Diuretics in the therapy of hypertension.J Hum Hypertens.2002,16(su