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inhibitionofc-metandpreventionofspontaneousmetastatic.ppt

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inhibitionofc-metandpreventionofspontaneousmetastatic

Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1 by Giuliana Cassinelli, Cinzia Lanzi, Giovanna Petrangolini, Monica Tortoreto, Graziella Pratesi, Giuditta Cuccuru, Diletta Laccabue, Rosanna Supino, Sara Belluco, Enrica Favini, Anna Poletti, and Franco Zunino Mol Cancer Ther Volume 5(9):2388-2397 September 19, 2006 ?2006 by American Association for Cancer Research Effects of RPI-1 (24 h of exposure) on Met tyrosine phosphorylation and expression in the N592 SCLC and the H460 NSCLC cell lines analyzed by immunoblotting. Giuliana Cassinelli et al. Mol Cancer Ther 2006;5:2388-2397 ?2006 by American Association for Cancer Research Effects of RPI-1 on Met-regulated signaling in H460 cells. Giuliana Cassinelli et al. Mol Cancer Ther 2006;5:2388-2397 ?2006 by American Association for Cancer Research Inhibition of anchorage-independent cell growth. Giuliana Cassinelli et al. Mol Cancer Ther 2006;5:2388-2397 ?2006 by American Association for Cancer Research Cell migration and Matrigel invasion assays. Giuliana Cassinelli et al. Mol Cancer Ther 2006;5:2388-2397 ?2006 by American Association for Cancer Research Effects of RPI-1 (orally, 150 mg/kg, b.i.d.) on H460 s.c. growing primary tumors and lung metastases in nude mice. Giuliana Cassinelli et al. Mol Cancer Ther 2006;5:2388-2397 ?2006 by American Association for Cancer Research Antiangiogenic effects of RPI-1. Giuliana Cassinelli et al. Mol Cancer Ther 2006;5:2388-2397 ?2006 by American Association for Cancer Research Effects of RPI-1 (24 h of exposure) on Met tyrosine phosphorylation and expression in the N592 SCLC and the H460 NSCLC cell lines analyzed by immunoblotting. A, Met and actin expression analyzed on whole-cell lysates (WCL). B, constitutive tyrosine phosphorylation of Met immunoprecipitated (IP) from serum-starved cells. C, effects of RPI-1 on Met tyrosine phosphorylation and expression. Met was immunoprecipitated from cell extracts and subjected to anti-ph