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Interface dermatitis A method based on epidermal changes Philip E. LeBoit, M.D. Depts. of Pathology and Dermatology University of California, San Francisco I. Introduction An inflammatory skin disease in which the junction between the papillary dermis and epidermis is obscured is termed an interface dermatitis. In most of these diseases T lymphocytes infiltrate the basal layer of the epidermis (and oftentimes the lower spinous layer as well) and cause cytotoxic damage to, or kill keratinocytes by the induction of a form of cell death known as apoptosis (1). Apoptotic keratinocytes becom