【2017年整理】手性药物拆分技术的研究进展.docVIP

手性药物拆分技术的研究进展 作者：付涛 　　【摘要】 简要阐述了手性药物的世界销售市场。综述了目前实验室和 工业 生产领域手性药物的拆分方法，包括：结晶拆分法，化学拆分法，动力学拆分法，生物拆分法，色谱拆分法，手性萃取拆分法和膜拆分法等，并简要介绍了每种方法的情况及优缺点。 　　【关键词】 手性药物；外消旋体；手性拆分 　　Abstract：In this paper, the global market of chiral drugs were summarized. Chiral resolution techniques were briefly reviewed according to recent references, both those already in commercial practice and emerging technologies in labs, including crystallization, chemical, ferment, chromatographic, chiral extraction and membranous. The merit and defect of every methods were discussed. 　　Key words：Chiral drug; Raceme; Chiral separ