标题替加环素治疗ICU内第三类型腹膜炎疗效观察.docVIP

替加环素治疗ICU内重症腹腔感染疗效观察及预后评估 田佳，周忠义，谢晓红 海南省人民医院 重症医学科　海口 570010 作者简介：田佳，男，内科博士，工作单位：海南省人民医院重症医学科。职称：主治医师 【摘要】 目的：研究替加环素对于ICU内重症腹腔感染的治疗作用及预后。方法：选取诊断为重症腹腔感染的患者100例。观察组50例，对照组50例。对照组应用泰能联合稳可信抗感染治疗，观察组在对照组基础上给予替加环素。观察患者体温、WBC、NE、CRP、PCT及细菌清除率。结果：治疗后7－15天观察组总有效率84%。对照组总有效率68%。观察组培养到细菌30株。清除22株，清除率为73％，对照组培养到细32株，清除18株，清除率为56％，观察组住ICU时间、抗生素使用时间及28天死亡率较对照组明显减少。结论：替加环素对于ICU内重症腹腔感染有较好的治疗效果，改善预后。 【关键词】替加环素 腹腔感染 ICU 预后评估 Tigecycline treatment evaluation of curative effect and prognosis of severe abdominal cavity infection in ICU Tian Jia, Zhou Zhongyi, Xie Xiaohong Hainan Provincial Peoples Hospital intensive medicine, Haikou 570010 [Abstract] Objective: To study the effects of tigecycline for the treatment and prognosis of severe abdominal cavity infection in ICU.Methods: select 100 cases diagnosed with severe abdominal infection patients, 50 cases in observation group, 50 cases in the control group. The control group applied Tienam joint stability credible anti infection treatment, the observation group in the control group was given on the basis of tigecycline. Observation of patients with body temperature, WBC, NE, CRP, PCT and bacterial clearance rate.Results: 7-15 days after treatment, the observation group, the total efficiency of 84%. The comparison group total effectiveness 68%. The observation group were cultured to the 30 strains of bacteria. 22 strains of clearance, clearance rate was 73%, control group training to fine of 32 strains, 18 strains of clearance, clearance rate was 56%, the observation group ICU stay time, the use of antibiotics in time and 28 day mortality decreased obviously than that in control group.Conclusion: tigecycline for ICU patients with severe abdominal infection has good treatment effect, improve the prognosis. [keyword] tigecycline abdominal infection ICU prognosis 前言 重症腹腔感染是指由于各种原因导致感染扩散至腹膜腔，引起腹膜炎或腹腔脓肿后发生脓毒血症甚至多器官功能衰竭而危及生命。重症腹腔感染在外科手术后较为常见，有较高的病死率。随着抗菌药物广泛以及不规范使用，临床抗菌药物的耐药状况日趋严峻，被称之为“超级细菌”的多重耐药菌已呈现出全球蔓延的态势，导致临床医生在面对此类细菌导致的感染