ppt课件-3 d finite element modelof medial meniscus meniscectomy（三维有限元modelof内侧半月板半月板切除术）.pptVIP

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2017-01-25 发布于四川
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ppt课件-3 d finite element modelof medial meniscus meniscectomy（三维有限元modelof内侧半月板半月板切除术）.ppt

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Meniscal Tissue Degradation as the first sign of Osteoarthritis. THE PROCESS OF MECHANOTRANSDUCTION IN THE MENISCAL TISSUE. Structure of the Meniscus C-shape (wedge-shape in cross-section profile) disks of fibro cartilage Interposed between the condyles of the femur and tibia Motivation Studies show that the meniscus is involved in the early stages of OA development. A better understanding of the loading environment and biochemical response of meniscal tissue may help us understand the etiology of OA. Project definition FE model of medial partial meniscectomy MEASUREMENT OF THE CHANGES IN THE CONTACT PARAMETERS ON THE MENISCUS AFTER DIFFERENT PARTIAL MENISCECTOMIES Biochemical tests on the post incubated media MEASURMENTS OF THE AMOUNT OF VARIOUS MOLECULES RELEASED INTO THE MEDIA AFTER DIFFERENT LOAD CONDITIONS Real time RT-PCR MEASURMENT OF THE GENE EXPRESSION IN THE MENISCAL TISSUE AFTER DIFFERENT LOAD CONDITIONS Clinical Treatment of Meniscal Tears Meniscal repair Does not heal in avascular zone (Arnoczky, S.P. 1992; King, D. 1936) Allograft Poor fixation technique Difficulties with finding a donor of correct size (Paletta, G.A.,et al., 1997; Peters, G.A. et al.,2003; Felixs, N.A. Paulos, L.E., 2003) Partial meniscectomy Changes in contact area and stress distribution contribute to osteoarthritis (OA) (Baratz, M.E. et. al., 1986; Fukubayashi, T. Kurosawa, H., 1980; Cole, B.J., 2004; Rangger, C., et al., 1995; Cox, J.S., et a;., 1975; Wyland, D.J., et a;., 2002; Fahmy, N.R.J et al., 1983) Aims of the study Examine changes in contact parameters on superior surface of meniscus after medial meniscectomy. Examine changes on lateral meniscus after medial meniscectomy. Finite Element Model Simulations of Medial Partial Meniscectomies Intact CaseMEDIAL MENISCUS, SUPERIOR SIDE Measurement of GAGs Release of GAGs into the media after load from tissue explants is a sign of tissue matrix destruction. Measurement of PGE2 PGE2, an intracellular signali