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* Acknowledgements Karan Takahashi Grace McNally Raphael Brykman Steven Wolfgang Elizabeth Philpy * These aforementioned trends to specialization and loss of domestic API manufacturing base are borne out by registration statistics. 941 foreign API manufacturers vs. 149 domestic API manufacturers. 86% of registered API manufacturing sites are outside US 1924 foreign FDF manufacturers vs. 2377 domestic FDF manufacturers. 45% of registered FDF manufacturing sites are outside US. There are about twice as many foreign sites registered as FDF manufacturers as there are foreign sit