肌酸激酶与孕酮在持续性输卵管妊娠中的意义.docVIP

肌酸激酶与孕酮在持续性输卵管妊娠中的意义 ［摘要］ 目的:回顾性分析输卵管妊娠行保守手术后发生持续性输卵管妊娠的患者术前24 h肌酸激酶、孕酮的水平，以探讨术前肌酸激酶、孕酮的水平在预测持续性输卵管妊娠发生中的价值。方法:确诊为输卵管妊娠拟行腹腔镜下输卵管保守手术的住院患者(排除患有其他疾病者)76例，其中发生持续性输卵管妊娠16例，非持续性输卵管妊娠60例。测定术前24 h肌酸激酶、孕酮的水平，回顾性分析术后确诊为持续性输卵管妊娠和非持续性输卵管妊娠这两组中肌酸激酶、孕酮的数值。结果:持续性输卵管妊娠组孕酮均值10.2　ng/ml, 非持续性输卵管妊娠组孕酮均值4.3 ng/ml，两组比较差异有统计学意义(P＜0.05)；持续性输卵管妊娠组肌酸激酶均值102.3 μ/L，非持续性输卵管妊娠组肌酸激酶均值60.5 μ/L，两组比较差异有统计学意义(P＜0.05)。结论:持续性输卵管妊娠中血清肌酸激酶活性与孕酮水平有相关性，术前24 h血清肌酸激酶、孕酮的水平在预测持续性输卵管妊娠的发生有一定的参考意义。 　　［关键词］ 持续性输卵管妊娠；孕酮；肌酸激酶 　　Significance of Analyzing the Creatine Kinase and Progesterone in Persistent Ectopic Pregnancy 　　LIU Min, GUO Yanling, LU Xin 　　(Women and Children Health Care Hospital of Haidian, Beijing 100080, China) 　　Abstract:Objective To evaluate the role of creatine kinase and progesterone in predicting the incidence of persistent ectopic pregnancy after performing therapeutic laparoscopy.Methods To retrospective analysis the serum level of creatine kinase and progesterone before performing therapeutic laparoscopy in ectopic pregnancy. Results The activity of serum creatine kinase and serum progesterone value were significantly higher in persistent ectopic pregnancy than in the none persistent ectopic pregnancy (P＜0.05) before performing therapeutic laparoscopy. The activity of serum creatine kinase has positive relevance with serum progesterone value (P＜0.05) in persistent ectopic pregnancy. Conclusion The activity of serum creatine kinase and serum progester one value before performing therapeutic laparoscopy in ectopic pregnancy maybe play a role in predicting the incidence ofpersistent ectopic pregnancy. 　　Key words:Persistent ectopic pregnancy ;Creatine kinase ; Progesterone 　　近年来异位妊娠发生率呈上升趋势，其中输卵管妊娠占异位妊娠总数的95%以上［1］。异位妊娠的保守治疗随着术前阴道B超和血清人绒毛膜促性腺激素、孕酮检测的广泛应用也得以广泛采纳。异位妊娠的保守治疗是指用药物、手术或持续观察等方法使输卵管功能仍就保留的一种治疗方法，其中腹腔镜下输卵管保守性手术是近年来广泛开展的一种微创手术。此种治疗方法具有不开腹、保留患者生育可能性优点的同时也增加了持续性输卵管妊娠发生的风险。持续性宫外孕指在宫外孕保守治疗过程中没有完全地移去胚囊，或没有完全地杀死胚囊，使残留的滋养叶细胞仍继续保留功能