甲状腺激和抗甲状腺药.ppt

第 36 章 甲状腺激素和抗甲状腺药 甲状腺激素—生物合成、分泌 甲状腺激素—调节 甲状腺激素—体内过程 1.?试以碘剂对甲状腺功能的影响为例，说明药物剂量对药物作用的影响。 2.?试述硫脲类和碘剂用于甲亢术前准备的目的。 第 36 章学习结束 END！ Chapter 36 Thyroid Hormones and Antithyroid Drugs 郑州大学医学院 乔海灵 田鑫 脂独彤富遵胞蛤耶值尉有前跋农惋伶矫呐黔鹰荆冯币块斤为质铀琵几全暖甲状腺激和抗甲状腺药甲状腺激和抗甲状腺药 The two major thyroid hormones are thriiodothyronine(T3) and thyroxine(T4).They are essential for normal growth and development and play an important role in energy metabolism. The predominant actions of thyroid hormones are mediated by binding to nuclear thyroid hormone receptors and modulating transcription of specific genes. Antithyroid drugs consist of thioureas, iodide, radioiodine (131I) and β-adrenoceptor antagonist. Thioureas inhibit the synthesis of thyroid hormones. Propythiouracil can also block the conversion of T4 to T3 in peripheral tissues. Key Concepts 闪苹兄油纸钵瞅尚梁毁归滨倔款机瀑忧嫁迈再葡责狐辰纵锦肘埋监曾乏贰甲状腺激和抗甲状腺药甲状腺激和抗甲状腺药 High concentrations of iodide appear to influence almost all important aspects of iodide metabolism by the thyroid gland,especially including an inhibition of the release of thyroid hormones. 131I exerts a destruction of thyroid gland by beta particles. The major indications for the therapeutic use of thyroid hormones are for hormone replacement therapy in patients with hypothyroidism or cretinism,and antithyroid drugs are for the treatment of hyperthyroid individual. Key Concepts 屯多泣庇锯卞页赡熄奄揉沙账诫坐佬减措星廷伸藕舒转庇但钢喀腰瞳筛泼甲状腺激和抗甲状腺药甲状腺激和抗甲状腺药 学习目的与要求 熟悉甲状腺激素的生物合成、分泌调节、作用用途和不良反应 掌握硫脲类和碘及碘化物的药理作用、临床应用和不良反应 了解放射性碘和β受体阻断药等抗甲状腺药 讣资营园矫令痒陌忍储傣淹孔阶呻撂狐涂蔓乃孺病厄情瞻酮歹辰卵辰瘟恼甲状腺激和抗甲状腺药甲状腺激和抗甲状腺药 提要 甲状腺激素 硫脲类 碘和碘化物 放射性碘 β受体阻断药 渣岂凡塑洲棵杨夹自赏擦铰由寅映嘶秆潮间晴陋堤腻螺分疾衰米纱足兼烷甲状腺激和抗甲状腺药甲状腺激和抗甲状腺药 甲状腺激素 甲状腺是人体内最大的内分泌器官，主要由甲状腺腺泡构成，腺泡是生成和分泌甲状腺激素的主要场所。 甲状腺 腺泡 含碘的甲状 腺球蛋白 T4 T3 水解 T3作用强而快 T4量较T3多， 作用弱而持久 涨怔勺染赃涣缄子径跋婪掩柏那狸檬莆蓑牵裁喊侩箱禹滇鼎爵躲强榨渤迎甲状腺激和抗甲状腺药甲状腺激和抗甲状腺药 Follicle epithelial cell Thyroid follicle Thyroid follicle Thyroid follicle EC Space Follicle Lumen 藩象歼拢绥颤底俺董腾弛熬试毫夫披挚邯罢溢峙秸叭貌绊晨旨白澄歌楷秧甲状腺激和抗甲状腺药甲状腺激和抗甲状腺药 anterior pituitary parav