精神分裂症药物治疗解决方案.ppt

* 12 Kaplan-Meier Survival Plot of Time to Relapse Kaplan-Meier survival probability plot of time to relapse indicated a treatment group difference that was statistically significant (P=.001) based on stratified log-rank test controlling for investigator and gender. The time to relapse in the risperidone group was prolonged when compared to the time to relapse for the haloperidol group. The mean time to relapse was 452 and 391 days for the risperidone and haloperidol groups, respectively. The last observations of both treatment groups were censored, so in each case the mean time to relapse could be underestimated. * * Slide 94. All antipsychotics studied were associated with some degree of prolongation of the QTc interval. No patient had a QTc interval of 500 msec at any time during the study. The 95% confidence interval (CI) for the changes observed with ziprasidone overlapped only with haloperidol. There was no overlap between the lower 95% CI of the mean change associated with thioridazine and the upper 95% CI for any other agent studied.36 * * * Data presented show 95% confidence intervals for estimated weight change after 10 weeks of treatment with standard drug doses (estimated from a random effects model). Patients receiving placebo treatment lost an average of 0.74 kg (1.63 lb) and molindone was also associated with weight loss. For the remaining drugs, the degree of weight gain ranges from 0.04 kg (0.09 Ib) for ziprasidone to 4.45 kg (9.8 lb) for clozapine. Quetiapine weight change was estimated at 6 weeks, as 10 week data were not available. References: Allison DB, Mentore JL, Heo M et al. Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 1999;156:1686?696. * 相对危险度（OR值＝odds ratio)是指，与设定人群比，所罹患某种疾病的风险。相对危险度越高，风险越大。被设定的人群相对危险度为1. * * * 抗精神病药物与心源性猝死 166324名患者中478例发生，也就是年猝死发生率2.9‰ 高剂量治疗者的年猝死发生率3.3‰ 危险度评估为“中度”或“低度”，而不是“极少” Schneeweiss, et al. N Engl J Med 2009; 360:294-6 Ray, et al. N Engl J Med 2009; 360:225-35