神经营养因子与退行性神经系统疾病.docVIP

神经营养因子与退行性神经系统疾病 来源：解剖科学进展 作者：王昭金万选才 2004-9-30 摘　要：近年来随着对神经营养因子作用研究的不断深入，人们提出了神经营养因子是否对退行性或创伤中枢神经系统疾病有治疗作用的问题，本文将综述神经营养因子在生物学方面的最新发现，特别是神经营养因子的作用、及有关对中枢神经退行性疾病可能有治疗作用的内容参考文献： 　　［1］Partterson PH and Nawa H. Neuronal differentiation factor/cytokines and synaptic plasticity. Neuron, 1993, 10(6): 3507 　　［2］Ip NY. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 gignal transducing receptor component gp130. Cell, 1992, 69(5): 1121 　　［3］IP NY and Yancouplos CD. Neurotraphic factors and their receptors. Ann neurol, 1994, 35(1): s9 　　［4］Claterbuck RE and Price DL. Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons. J Comp neurol, 1994, 342(1): 45 　　［5］Korsching S. The neurotrophic factor concept: a reexamination. J Neurosci, 1993, 13(8): 2739 　　［6］Sendmer M, Kreutzbery GM and Thoenen H. Ciliary nerurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature, 1990, 345(2): 440 　　［7］Knusel B and Winslow JW. Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin-3. Proc Natl Sci USA,1991, 88(3): 961 　　［8］Zhou J, Pliego-Rivevo B, Bradford H, et al. The BDNF content of postnatal and adult rat brain, the effects of 6-hydroxydopamine lesions in adult brain. Develop Brain res, 1996, 97(2): 273 　　［9］Hyman C and Hofor M. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature, 1991,350(2): 230 　　［10］Haque NSK, Hlauim ML,Fawcett JW,et al. The neurotrophin NT-4/5, but not NT-3, enhance the efficacy of nigral grafts in a rat model of Parkinson’s disease. Brain res, 1996, 712(1),45 　　［11］Siuciak JK,Boylan C,Fristeh M, et al. BDNF increase monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration. Brain res, 1996, 712 (1):11 　　［12］Levi-Montalcini R. The nerve growth