血栓性微血管病课件.pptVIP

血栓性微血管病Thrombotic microangiopathy 血栓性微血管病 溶血性尿毒症综合征 血栓性血小板减少性紫癜 恶性高血压 硬皮病肾危象 妊娠肾病 药物性内皮细胞损伤 背景 A 16 year old girl anemia, petechiae, fever and renal involvement “Acute febrile pleiochromic anemia withy hyaline thrombosis of terminal arterioles and capillaries” Moschowitz Arch Intern Med 1925;36:89-93 Four similar cases Anemia and thrombocytopenic purpura Thrombi---agglutinating platelets Baehr et al. Trans Assoc Am Phys 1936;51:43-58 Thrombotic thrombocytopenic purpura (TTP) Hemorrhagic diathesis Generalized platelet thrombosis Singer et al. Blood 1947;2:542-554 Thromboti