Sepsis败血症培训教程文件.pptVIP

Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients Andrew Rhodes, Stephen J Wort, Helen Thomas,et al Crit Care. 2006;10(2):R60 Critical Care (1466-609X) Critical Care: 危重症医学 IF: 3.11(2006); 3.83(2007) Scope: in all areas of intensive care and emergency medicine.Cardiology, Infection, Metabolism, MOF/Sepsis, Nephrology, Neurology, Paediatrics, Resource Management, Respirology, Shock, Toxicology, Trauma and Resuscitation Advisory Board:Pro.Bin Du(杜斌)Director, Medical ICUPeking Union Medical College Hospital, China Feature Online: From January 2006 Critical Care is not available in print and is only published online. () Fast: An initial decision on manuscript submission within 5 weeks ,publication online within 28 days. allows authors to include additional files such as films or large datasets Background Prognosis of patients is important in risk stratification(危险度分级) and for efficient use of hospital resources.  Numerous biomarkers have been evaluated to predict morbidity and mortality in the intensive care setting:cytokines, procalcitonin, CRP, BNP, cTn Recently interest has developed in the use of plasma DNA, or cell-free nucleic acid, as a prognostic marker. The plasma DNA concentration taken soon after the accident is predictive of death with a sensitivity and a specificity of 100% and 81%, respectively. (by Lo YM) Sepsis is a major cause of morbidity and mortality in patients in the ICU and is associated with cell necrosis and apoptosis. Aim To assess the significance of raised levels of plasma DNA on admission to the intensive care unit (ICU) in terms of its ability to predict disease severity or prognosis. Materials and methods Cases: 52 ; Control: 10 healthy volunteers Characteristics: reason for admission, complications in the first 24 hours, length of stay, ICU and hospital mortality, SOFA score(感染相关的器官衰竭评分) Patients were followed up three months after discharge from the ICU. Sample Collectio