ACR关于DMARDs在RA合并HBV感染患者中的应用.docVIP

American College of Rheumatology 2008 Recommendations for the Use of Nonbiologic and Biologic Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis Liver contraindications. Abnormal liver transaminases.\ When the levels of liver transaminases (aspartate aminotransferase or alanine aminotransferase) were greater than 2-fold the upper limit of normal, the TFP recommended that the initiation or resumption of leflunomide, methotrexate,and sulfasalazine was contraindicated (although recommendations on when to discontinue are not provided).There are a large number of studies addressing l