含有药物活性物质的过渡金属配合物的合成讲解.doc

摘要 近几十年来，过渡金属配合物药物研究不断取得突破性成就，其在抗菌、抗肿瘤和抗病毒等方面都具有一定优势，具有很大的开发潜力和良好的应用前景。 本文基于分子设计的思想，以二价的Co、等为中心离子，1，4-双(咪唑-1-基)丁烷（bbi）、对羟基苯甲酸等为配体，合成了种金属配合物，并 Abstract In recent decades, transition metal complexes drug research breakthrough achievements unceasingly, its antibacterial, antitumor and antivirus, etc have certain advantages, has great development potential and good application prospect. In this paper, based on the idea of molecular design, with bivalent Cu, Co, Mn ions for the center, such as benzene tetracarboxylic acid, 1, 4 - double (imidazole - 1 -) butane (bbi), p-hydroxy benzoic acid as ligand, four new transition metal complexes were synthesized, and by X-ray single crystal diffraction, elemental analysis, IR, etc. To characterize the crystal structure. Complexes 1: by X-ray single crystal diffraction, complexes 1 in two separate copper center, two bivalent copper center are distorted octahedral configurations. Benzene tetracarboxylic acid as bridging ligand separation through the carboxyl oxygen and adjacent Cu (1) the center coordination, the formation of one-dimensional infinite chain structure [Cu (C10H2O8) (C3H4N2) 2 (H2O) 2] n. And Cu (2) the central atom respectively with four imidazole and two water ligand form zero dimensional structure fragment Cu (C3N2H4) 2 (C2N3H3) 2 (H2O) 2. Complexes 2: by IR, element analysis and thermogravimetric analysis, characteristic peak can be used to deduce the complexes containing both p-hydroxy benzoic acid, and contains bbi, so you can determine cobalt complexes 2 is p-hydroxy benzoic acid and bbi complexes. Complexes 3: by IR, element analysis, can determine cobalt complexes 3 is p-hydroxy benzoic acid and bbi complexes. Complexes 4: by IR analysis and characterization the appearance of the complexes can be concluded that cobalt complexes 4 is p-hydroxy benzoic acid and bbi complexes. Key words: transition metal complexes; Pharmacological activity; Single crystal; synthetic 目 录摘 要 I Abstract II 1