DEVELOPMENT OF THE UROGENITAL SYSTEM泌尿生殖系统的发展.pptVIP

ORGANOGENESIS OF THE UROGENITAL SYSTEMS. M.A.KAI-KAI  Learning Objectives This lecture will discuss: The derivatives of the intermediate mesoderm Incuding; the formation of the nephric systems the formation of the genital ducts the formation of the gonads the formation of the external urinary and genital organs Overview of organogenesis of the urogenital organs Sequence of development of the metanephros(1) Metanephros develops at somites 26-28 from 2 precursors -- ureteric bud(UB) and metanephrogenic mass [A,(MM)] Formation UB and MM is by reciprocal inductive interactions between the tissues. The diverticulum forms caudal of the existing mesonephric duct and grows and into the MM at the nephrogenic plate UB forms the duct system MM forms nephrons The ureteric bud branches as it grows towards the metanephrogenic mass(B) Morphogenesis of the ureteric bud2) The ureteric bud forms the duct system The metanephrogenic mass forms the nephrons by nephrogenesis. Nephrogenesis and differentiation of the ureteric bud are co-ordinated Dichotomous branching pattern of the ureteric bud is species specific. Branching of simple unilobar/ unipyramidal kidneys(dog,horse) the proximal end dilates into a renal pelvis with collecting ducts at the tip In multipyramidal kidneys(ox) ureter bifurcates into 2 major calyces and several minor calyces then collecting ducts Development of the metanephros(3) Stages in nephrogenesis. Solid cluster of metanephrogenic mass forms(A) and hollows into a renal vesicle(B) with epithelial lining this elongates into metanephric tubules (C). Proliferation,elongation of the MM dependent upon reciprocal tissue interactions using several molecular signals?tubules grow and form parts of nephrons. Nephrogenesis. Formation of glomerulus Proximal tube forms PCT, end dilates and invaginates to form the Bowmans capsule(D) Distal tube forms DCT and fuses with the collecting tubule. BC invaded by the