制备高尔夫球状的PLGA微球.docVIP

?View PDF VersionView Previous ArticleView Next Article DOI:10.1039/C0CC01738H (Communication) Chem. Commun., 2010, 46, 7433-7435 Golf ball-shaped PLGA microparticles with internal pores fabricated by simple O/W emulsion? Mi Ri Kim? a, Seungwoo Lee? b, Jung-Ki Park *b and Kuk Young Cho *a aDivision of Advanced Materials Engineering and Institute for Rare Metals, Kongju National University, Cheonan, Chungnam, 331-717, Korea. E-mail: kycho@kongju.ac.kr; Fax: +82-41-568 5776 bDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Engineering, Daejeon, 305-701, Korea. E-mail: jungpark@kaist.ac.kr; Fax: +82-42-350-3910 Received 4th June 2010 , Accepted 19th August 2010 First published on the web 3rd September 2010 Simple oil-in-water emulsion led to structural complexity at both the surface and interior of the PLGA microsphere. A golf ball-like dimpled surface comes from the heteroaggregation of volatile nonsolvent colloid originating from the inside of the organic droplet as supported by in situ optical microscopy . The internal porous structure and encapsulation of hydrophobic agent inside the microparticle implies its potential application as a drug carrier . Biodegradable polymer microparticles have been widely used as sustained release depot systems for drugs , personal care ingredients, and medical imaging agents.1 Physical parameters such as nano-/micron-scale internal structures, surface morphology, and size distributions are critical, in that they can play an important role in the control of loading efficiency, release kinetics and biological activities of the encapsulated substances. Thus, considerable efforts are being made to precisely control these features. In particular, considering the microparticle as a carrier for active agent, the main focus is on the control of internal pore structures of microparticles such as providing microparticles with a controlled hollow interior and porous wall.2 Recently the