L-T4BioequivalencePotentialImpactonIQinBabieswith.pptVIP

L-T4 Bioequivalence: Potential Impact on IQ in Babies with Congenital Hypothyroidism Rosalind Brown MD, Children’s Hospital, Boston Harvard Medical School Congenital Hypothyroidism Because newborns are asymptomatic at birth, screening programs developed worldwide Incidence 1 in 3,000 One of the commonest treatable causes of mental retardation Untreated CH Patients at Risk for Severe Mental Retardation IQ of CH patients is normal if treatment early and adequate But small differences in T4 dose have enormous impact on IQ Conclusions Small differences in L-T4 dose can have significant, irre