线纹香茶菜中木脂素的分离与结构鉴定.docVIP

Isolation and structure identification of lignans from Rabdosia lophanthoides(Buch.-Ham.ex D. Don)Hara. Feng Wei-sheng1, Zang Xin-yu1, Zheng Xiao-ke2, Wang Yan-zhi1, Li Hong-wei1 and Li Zhen1 (1. School of Pharmacy 2. Basic Medical College, Henan University of Traditional Chinese Medicine, 1 Jinshui Road, Zhengzhou 450008,China) Abstract: To study the chemical constituents of Rabdosia lophanthoides(Buch.-Ham.ex D. Don)Hara. Various columns including Diaion HP-20, Toyopearl HW-40C, Sephadex LH-20, silica gel were employed for the isolation and purification of compounds from Rabdosia lophanthoides(Buch.-Ham.ex D. Don)Hara.. The structures of the compounds were elucidated by their physiochemical characteristics and spectral data. Two new dihydrobenzofuran lignanosides, lophanthoside B (1) and a enantiomer of Umbroside (2), along with seven known lignans (3-9), were isolated from Rabdosia lophanthoides (Buch.-Ham.ex D.Don) Hara. Compound 1-6 was solated from this species for the first time, all the compounds were isolated from this plant for the first time. Key words: Rabdosia lophanthoides; chemical consitituents; lignans. 线纹香茶菜中木脂素的分离与结构鉴定 冯卫生*1，臧新钰1，郑晓珂2，王彦志1，李红伟1，李振1 (河南中医学院.药学院;.基础医学院,郑州 450008) 摘要：为研究的化学成分我们用Diaion HP20，Toyopearl HW-40C，Sephadex LH-20，silica gel等柱色谱方法进行分离根据其理化性质和波谱数据鉴定化合物结构分离得到个 lophanthoside B (1)和一个Umbroside的对映体(2), 以及七个已知的木脂素类化合物。其中化合物1-6为首次从该属植物中分到，所有的化合物均为首次从线纹香茶菜中分到。 关键词：线纹香茶菜；化学成分；木脂素 Isodon (=Rabdosia) is a cosmopolitan and important genus of the Labiatae(=Lamiaceae) family. About 150 species of undershrubs, sub-undershrubs or perennial herbs are found throughout the world mainly in tropical and subtropical Asia. The use of Isodon species in Chinese popular folk medicine has a long tradition. Most herbs of this species have been found to have obvious biological activities with low toxicity. Rabdosia lophanthoides (Buch.-Ham.ex D.Don)Hara. has been using for the treatment of acute icteric hepatitis, acute cholecystiti, sphagitis